Dissertation Defense Announcements

Candidate Name: Jessica N. Hoyle
Title: Social Capital and Developmental Disabilities: Interdependence to Promote Health
 July 18, 2023  2:00 PM
Location: CHHS 332 and Zoom (Meeting ID: 946 8211 7710 Passcode: 646904)
Abstract:

This dissertation describes three studies examining how people with developmental disabilities (DD) experience social capital from childhood to young adulthood. The first study follows PRISMA standards for scoping literature review to investigate social capital in DD research from childhood to emerging adulthood. Results describe social capital definition, measurement and application in DD research and identify gaps in the literature. The second study describes extracurricular activity (EA) participation of children with and without DD and the associations of childhood EA with mental health in young adulthood. Results show: differences in EA participation of children with and without DD; EA is associated with lower psychological distress and greater flourishing among people with and without DD. The third study uses photovoice to address the meaning of interdependence for college students with DD. Participants described their experiences using photos and stories. Themes included: openness to being helped, foundational role of families, experiencing new and challenging things, and tension between wanting to help and vulnerability of being a helper. Understanding social capital in the lives of people with DD can guide policies and supports, promoting improved quality of life. This research is a steppingstone toward a more inclusive and supportive society for people with DD.



Candidate Name: Lilian Ouja Ademu
Title: Three Essays on Infant and Young Child Feeding and Child Health Outcomes in Sub-Saharan Africa: An Epidemiology and Policy Analysis
 July 10, 2023  11:00 AM
Location: Zoom
Abstract:

Exclusive breastfeeding in the first six months of life and continued complementary breastfeeding until a child is 24 months is encouraged to ensure optimal infant and young child nutrition and health. The WHO and UNICEF emphasize these optimal Infant and Young Child Feeding (IYCF) practices, especially for regions of the world where extensive child nutrition and healthcare support is lacking or inaccessible.
This dissertation explores the epidemiology of IYCF practices and child health outcomes in sub-Saharan Africa. It also examines the status of IYCF policies and programs in this relatively less studied region of the world. I use publicly available data from the Nigerian Demographic and Health Survey (NDHS) and the WHO/UNICEF Breastfeeding Collective scorecard to answer important questions explored across three studies.
Results from the first study suggest that longer durations of breastfeeding are associated with fewer reported acute illnesses post-infancy at 24 to 59 months; demonstrating the long-term protective effect of breast milk from illnesses that contribute to the high under-five mortality rates recorded for decades in sub-Saharan Africa.
Another important finding from the second study is that the relationship between exclusive breastfeeding, household living environmental conditions, and acute health outcomes in infancy is complex. The results suggest that the efficacy of exclusive breastfeeding in reducing the incidence of diarrhea and acute respiratory illness is strongest for infants living in households with poor sanitation facilities and inadequate building materials respectively. Lastly, results from the third study indicate that sub-Saharan Africa as a region is yet to meet global and WHA targets on the implementation of many IYCF policies and programs. These findings have implications for child nutrition and health outcomes in especially for a region already disproportionately impacted by high under-five mortality rates.



Candidate Name: Lilian Ouja Ademu
Title: Three Essays on Infant and Young Child Feeding and Child Health Outcomes in Sub-Saharan Africa: An Epidemiology and Policy Analysis
 July 10, 2023  11:00 AM
Location: Zoom
Abstract:

Exclusive breastfeeding in the first six months of life and continued complementary breastfeeding up to 24 months is encouraged to ensure optimal infant and young child nutrition and health. The WHO and UNICEF emphasize these optimal Infant and Young Child Feeding (IYCF) practices, especially for regions of the world where extensive child nutrition and healthcare support is lacking or inaccessible.
This dissertation explores the epidemiology of IYCF practices and child health outcomes in sub-Saharan Africa. It also examines the status of IYCF policies and programs in this relatively less studied region of the world. I use publicly available data from the Nigerian Demographic and Health Survey (NDHS) and the WHO/UNICEF Breastfeeding Collective scorecard to answer important questions explored across three studies.
Findings from the first study suggest that longer durations of breastfeeding are associated with fewer reported acute illnesses post-infancy at 24 to 59 months; demonstrating the long-term protective effect of breast milk from illnesses that contribute to the high under-five mortality rates recorded for decades in sub-Saharan Africa. Another important finding from the second study is that the relationship between exclusive breastfeeding, household living environmental conditions, and acute health outcomes in infancy is complex. The results suggest that the efficacy of exclusive breastfeeding in reducing the incidence of diarrhea and acute respiratory illness is strongest for infants living in households with poor sanitation facilities and inadequate building materials respectively. Lastly, findings from the third study indicate that sub-Saharan Africa as a region is yet to meet global and World Health Assembly targets for the implementation of recommended IYCF policies and programs. These findings have implications for child nutrition and health outcomes in especially for a region already disproportionately impacted by high under-five mortality rates.



Candidate Name: Jordan Register
Title: Designing for High School Students' Ethical Mathematics Consciousness in an Introductory Data Science Course
 July 26, 2023  10:00 AM
Location: Hybrid: In person: CHHS 109; Zoom link (https://charlotte-edu.zoom.us/j/96937007252?pwd=RU45N1YvbUhuZFp4RnRnVmUvRnM1QT09)
Abstract:

The increased reliance on Big Data Analytics (BDA) in society, politics, policy, and industry has catalyzed conversations related to the need for promoting ethical reasoning and decision-making in the mathematical sciences. While the majority of professional data scientists today come from privileged positions in society, those processed by the decisions made using data science are more often members of one or more marginalized social groups, translating into disproportionately negative outcomes for these individuals in society. Thus, it is argued that future citizens must develop an ethical mathematics consciousness (EMC) that human beings do mathematics; thus, there are potential ethical dilemmas and implications of mathematical work which may affect entities at the individual, group, societal, and/or environmental level. Drawing from this conjecture, the purpose of this Design-based research study was to develop a local instruction theory and materials that promote students’ ethical mathematics consciousness in a high school Ethical Data Science (EDS) course grounded in a feminist, relational ethic of caring and social response-ability. Outputs include the identification of design heuristics, including the task structures, participation structures, and discursive moves that supported students' development of EMC and equitable participation in classroom activities, an initial curriculum for the EDS course, and a student-use protocol and corresponding analytic framework for making critically conscious ethical decisions in data science.



Candidate Name: Khyati Mahajan
Title: Towards Multi-Party Conversation Modeling
 July 19, 2023  1:30 PM
Location: https://charlotte-edu.zoom.us/j/92443196381?pwd=bmhNTmNKWHdyTHhIVjdMSXNSMlY3UT09
Abstract:

Recent advances in the field of Natural Language Processing, specifically in Natural Language Generation (NLG) towards Dialogue Systems have focused mainly on two-party conversations. However, group conversations or multi-party conversations (MPC) are just as prevalent in our everyday lives. While the area of multi-party conversation modeling has received some attention in recent times, MPC lacks resources for 1) corpora in differing settings (formal/informal, synchronous/asynchronous), 2) dialogue models which can participate in informal open-domain settings while maintaining speaker information, and 3) evaluation metrics which provide better insights into the performance of MPC models when it comes to operating in groups and interacting with multiple participants. We thus take a three-pronged approach towards contributing to research in the MPC modeling research area. For corpora collection, we contribute a mock social media tool that can be utilized for collecting asynchronous MPC conversations called Community Connect and utilize it for 3 experiments to collect everyday talk. For MPC modeling, we propose a response generation model, using large language models (LLMs) and graph structured networks, which is capable of taking participant relations into account towards maintaining multiple persona profiles and generating responses keeping the speaker characteristics in mind and responding accordingly. Lastly, for MPC evaluation, we present an expansion to the taxonomy of errors which specifically contributes MPC-specific metrics to the overall NLG errors. In addition to the taxonomy, we contribute to better evaluation standards across which progress in the tasks within MPC can be tracked more saliently. Through these contributions, we aim to fill the necessary gaps towards advancing MPC understanding and modeling, while also providing the tools to gauge progress until now.



Candidate Name: Damian Beasock
Title: Characterization of Dynamic and Functional Nucleic Acid Based Systems
 June 21, 2023  2:00 PM
Location: https://charlotte-edu.zoom.us/j/99910031489
Abstract:

Nucleic acids are highly integrated into molecular biology and exhibit very interesting character with immense engineering potential to improve human health and influence molecular biology. Consequently, these biopolymers are the quintessential material for facilitating natural and therapeutic functions in basic research, biomedicine, and biological sciences. The field of nucleic acid nanotechnology is a massive research endeavor to understand and take advantage of DNA and RNA. Progression of the field is evident with an increasing amount of therapeutic nucleic acids (TNAs) approved for clinical use and several TNAs (mRNA vaccines) proved to be highly efficient to address the SARS-CoV-2 pandemic. Nucleic acid nanoparticles (NANPs) are an innovative class of structures. Herein, a review of the field of nucleic acid nanotechnology is given to summarize the potential of the field. Then, a focus on NANPs is taken though experimental work that offers novel methods of restructuring and functional options. A novel assembly method via selective nuclease degradation of RNA/DNA hybrids is introduced and DNA templated silver nanoclusters, as a new class of therapeutics, are characterized to optimize their antibacterial function. These studies advance the development of functional nucleic acids for the treatment of diseases and the improvement of the quality of life.



Candidate Name: Jordan Register
Title: DESIGNING FOR HIGH SCHOOL STUDENTS’ ETHICAL MATHEMATICS CONSCIOUSNESS IN AN INTRODUCTORY DATA SCIENCE COURSE
 July 26, 2023  10:00 AM
Location: Hybrid: In person: Fretwell 315; Zoom link (https://charlotte-edu.zoom.us/j/96937007252?pwd=RU45N1YvbUhuZFp4RnRnVmUvRnM1QT09)
Abstract:

The increased reliance on Big Data Analytics (BDA) in society, politics, policy, and industry has catalyzed conversations related to the need for promoting ethical reasoning and decision-making in the mathematical sciences. While the majority of professional data scientists today come from privileged positions in society, those processed by the decisions made using data science are more often members of one or more marginalized social groups, translating into disproportionately negative outcomes for these individuals in society. Thus, it is argued that future citizens must develop an ethical mathematics consciousness (EMC) that human beings do mathematics; thus, there are potential ethical dilemmas and implications of mathematical work which may affect entities at the individual, group, societal, and/or environmental level. Drawing from this conjecture, the purpose of this Design-based research study was to develop a local instruction theory and materials that promote students’ ethical mathematics consciousness in a high school Ethical Data Science (EDS) course grounded in a feminist, relational ethic of caring and social response-ability. Outputs include the identification of design heuristics, including the task structures, participation structures, and discursive moves that supported students' development of EMC and equitable participation in classroom activities, an initial curriculum for the EDS course, and a student-use protocol and corresponding analytic framework for making critically conscious ethical decisions in data science.



Candidate Name: Lewis Alexander Rolband
Title: ASSESSING THE BIOLOGICAL ACTIVITIES OF DNA-TEMPLATED SILVER NANOCLUSTERS AND FURTHERING THE CHARACTERIZATION OF NUCLEIC ACID NANOPARTICLES
 June 12, 2023  11:45 AM
Location: Burson Hall; https://charlotte-edu.zoom.us/j/95122014793
Abstract:

DNA and RNA are structurally and functionally diverse biopolymers that have shown promise in recent years as a powerful biomedical tool, in the form of nucleic acid nanotechnologies. The applications of these technologies include biosensing, diagnostics, cancer therapeutics, vaccines, and many more. A relatively unexplored area to which nucleic acid nanotechnology is being applied is the field of antibacterial research. By combining short DNA oligos with silver cations, folding the DNA into its proper secondary and tertiary structures, then reducing the silver, DNA may template the formation of few-atom silver nanoclusters (AgNCs). Silver has been well understood for centuries to be an effective antibacterial agent. Many silver nanostructures have been investigated for their potential efficacy as antibiotics. DNA-AgNCs have been shown to be effective at preventing bacterial growth in a variety of conditions. A unique advantage of DNA-AgNCs is that, unlike many larger silver nanostructures which typically absorb light through surface plasmon resonance, AgNCs fluoresce in a manner dependent on the sequence and structure of the templating oligonucleotide(s). Due to the unique structure-function relationship of AgNCs, further investigation of their structure is warranted. Presented herein is a thorough review of silver nanomaterials, along with work demonstrating the effectiveness of a DNA-AgNC hairpin system against a model E. coli system, and the characterization of an RNA ring which may serve as the scaffold for a multitude of functionalities, including DNA-AgNCs, in preparation for future work.



Candidate Name: Rachel Siegal
Title: Reconceptualizing community violence research: Redefining safety using place-based methodologies and enhancing cross-sector data sharing models to inform community violence intervention efforts in Mecklenburg County, North Carolina
 June 07, 2023  10:00 AM
Location: Fretwell 202, https://charlotte-edu.zoom.us/j/93941169100?pwd=SHRSYlpyT2VMelE4QW9WaEZwby9rdz09
Abstract:

Community violence occurs primarily in public settings, frequently involves high-risk behaviors such as firearm use, and is often geographically concentrated as a result of racial and economic segregation enforced through policy and practice. Community violence has risen in Mecklenburg County, North Carolina over the past five years, with a plurality of incidents concentrated in neighborhoods which also have high rates of social, economic, and health-related risk factors. This dissertation builds on my work with the City of Charlotte and Mecklenburg County as part of a multi-sector collaboration intended to leverage resources and align programs and policies to disrupt, reduce, and prevent community violence. In this dissertation, guided by the Ecological Systems Theory and Social Determinants of Health Framework for Action, I used qualitative, quantitative, photographic, and geospatial data to (1) explore residents’ perceptions of safety and experiences of community violence; (2) describe an integrated, place-based methodology that can be used in community violence research; and (3) explore how positionality informs cross-sector, collaborative data sharing efforts to address community violence.

In study one, participants identified neighborhood features across ecological levels that contributed to them feeling safe or unsafe. Notably, participants perceived historical and on-going disinvestment, enacted through structural racism, as contributing to unsafe conditions. In study two, which grows out of study one, we found that walking interviews generated more findings specific to place and situated within the micro-, meso-, and exosystem levels, while more traditional, semi-structured sedentary interviews yielded results that were largely centered within the individual and microsystem levels. In addition, using an integrated methodology highlighted gaps in the publicly available quantitative data and demonstrated the utility of employing multiple methods to capture data related to place, most notably by generating data that informed actionable insights across ecological levels. In study three, we found that individuals’ and organizations’ social identities (e.g., individuals’ level of data knowledge and data sharing experiences, and organizations’ use of formal data sharing processes) as well as power (specifically, individuals’ sense of empowerment, and organizations’ use of resources and data sharing capacity) interacted to influence barriers and facilitators to data sharing.

Findings point to areas for future research and suggest local implications including (a) the need for increased attention in research and practice related to how structural racism contributes to unsafe neighborhood conditions; (b) the potential benefits of considering how the described integrated, place-based methodology can be scaled to capture residents’ perceptions of safety and experience of violence across neighborhoods; and (c) the salience of attending explicitly to how the positionality of the individual and organization contributes to barriers and facilitators to cross-sector data sharing. Results from my dissertation can be used locally to inform cross-sector, collaborative solutions to community violence that incorporate residents’ perspectives and address risk factors across ecological levels. While conducted in Mecklenburg County, results also have implications for community violence prevention and intervention efforts in communities across the country.



Candidate Name: Maya Uma Kapoor
Title: Data Mining and Deep Learning Systems for Network Traffic Classification and Characterization at Scale
 June 14, 2023  3:00 PM
Location: Woodward Hall
Abstract:

The real, complex network environment consists of an ever-increasingly diverse and large amount of data encapsulated in packets. Surveillance and monitoring of this traffic is a necessary task for law enforcement, cybersecurity, and intelligence agencies. Intercepted network traffic must be classified into multiple categories, such as the protocol encapsulation layers contained, application it originates from, user generating the traffic, and the traffic's malicious or benign nature. There is a lack of solutions which are able to classify packets individually without flow-based features. In order to address the gaps in current traffic classification and DPI techniques, we propose the initial release of the Forager toolkit, a software consisting of tools to extract hidden representations from individual packets and use these features in deep learning models to perform traffic classification. It uses data mining techniques to perform automatic generation of regular expression signatures, locality-sensitive hash fingerprints, and matrix and point cloud representations of packets. These are used as input features for corresponding deep learning models which can perform traffic classification on single packets in a real system. The models are multi-modal to capture multiple angles and dimensions of features for increased complexity of classification problems. They can be run in parallel for optimal throughput and scalability. Our experiments use these models in multiple configurations and scenarios to demonstrate superior performance and classification capability to advance the state of the art in complex network traffic surveillance and hidden representation learning.